Events1st International Electronic Conference on Medicinal Chemistry
Event submissions
Published
with-doi10.3390/ecmc-1-A027
This submission belongs to the session A. ECMC-1 of the event 1st International Electronic Conference on Medicinal Chemistry
Published date
02 Nov, 2015
Citation
Amalia Di Petrillo, Antonella Fais, Benedetta Era, Eugenio Uriarte, Fernanda Borges, Francesca Pintus, Lourdes Santana, Maria João Matos, Rosaria Medda, Adriana Murgia, Study of a Series of 8-Substitued 7-hydroxy-4-methylcoumarins as AChE and BuChE Inhibitors, in Proceedings of 1st International Electronic Conference on Medicinal Chemistry, 2 November–27 November 2015, MDPI: Basel, Switzerland, doi: 10.3390/ecmc-1-A027
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Study of a Series of 8-Substitued 7-hydroxy-4-methylcoumarins as AChE and BuChE Inhibitors

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Maria João Matos 1
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Fernanda Borges 2
Lourdes Santana 1
Eugenio Uriarte 1
Rosaria Medda 3
Adriana Murgia 3
Amalia Di Petrillo 3
Benedetta Era 3
Antonella Fais 3
Francesca Pintus 3
1. Departamento de Química Orgánica, Facultad de Farmacia, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain
2. CIQUP/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal
3. Department of Life Science and Environment, University of Cagliari, 09042 Monserrato, Cagliari, Italy
Abstract
In the current work we studied the interest of a series of 8-substitued 7-hydroxy-4-methylcoumarins as acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitors. For the best compounds of the series, the IC50 value was determined. This work was based on previous results and is a preliminary screening for further design and synthesis of new derivatives as potential compounds that can modulate enzymatic systems involved in the neurodegenerative diseases.
Keywords
8-Substitued 7-hydroxy-4-methylcoumarins • Acylation reaction • Acetylcholinesterase inhibitors • Butyrylcholinesterase inhibitors • Alzheimer’s disease
Poster
Matos et al.pdf
Matos et al.pdf
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