A Proposed Outcome Assessment Framework for Regenerative Endodontics: A Perspective for Future Collaboration

Aim: To propose a structured framework for standardized outcome assessment in regenerative endodontic procedures (REPs) and to provide a foundation for future collaborative development and validation.

Methods: This framework was developed through the synthesis of key outcome domains reported in human clinical studies and animal models and was informed by established biological principles and published position statements in regenerative endodontics. Because routine histologic validation is not feasible in human studies, a multidimensional composite outcome model was designed to integrate clinical, radiographic, and functional indicators of treatment response.

Result:The proposed framework consists of a multidimensional composite score integrating five outcome domains: (1) clinical symptom resolution, (2) periapical radiographic healing, (3) continued root development, (4) apical response, and (5) pulp sensibility as well as separate for histological evaluation or in vitro studies. Individual domain scores are combined and interpreted hierarchically to distinguish outcomes consistent with tissue repair from those suggestive of true regeneration and recommend follow-up intervals for outcome reporting

Conclusion:This proposed framework provides a structured and transparent approach to outcome assessment and reporting in regenerative endodontic procedures. By integrating multiple clinically relevant domains into a standardized scoring system, it may improve consistency and comparability across clinical and translational studies. Although not intended as a consensus guideline, it provides a foundation for future multicenter validation and consensus-driven refinement.