This study aimed to evaluate the effects of mouthrinses with different compositions, including whitening formulations, on the optical and surface properties of a leucite-reinforced glass-ceramic before and after hydrothermal aging. One hundred fifty polished specimens of IPS Empress CAD were assigned to either non-aged or hydrothermally aged conditions. Aging consisted of distilled-water storage at 37 °C for 6 months. Specimens were then immersed in distilled water, alcohol-free mouthrinse, alcohol-containing mouthrinse, conventional whitening mouthrinse, or an activated charcoal-based whitening mouthrinse for 60 and 120 hours, with daily solution renewal. Color, translucency, whiteness, gloss, surface roughness, and surface morphology were evaluated. Data were analyzed using repeated-measures analysis of variance (ANOVA) and the Tukey test. The effects were solution- and time-dependent. Alcohol-containing and conventional whitening mouthrinses induced greater optical and surface alterations, characterized by a progressive increase in roughness and a reduction in gloss. The activated charcoal-based whitening mouthrinse produced whiteness changes that exceeded the clinical acceptability threshold. Furthermore, hydrothermal aging intensified surface irregularities, particularly when combined with the whitening formulations. In conclusion, prolonged exposure to mouthrinses significantly affected the optical and surface properties of the leucite-reinforced glass-ceramic. These deleterious effects were more pronounced for alcohol-containing and whitening formulations, and were further exacerbated by hydrothermal aging. Therefore, mouthrinses may affect the properties of leucite-reinforced glass-ceramic.