MCM-41-SO3H as Heterogeneous Catalyst for One-pot Four Component Synthesis of Highly Substituted Pyrroles

Nanoporous heterogeneous catalysts have been applied in many reactions due to the high contact area and orderly porous structures with thermal, chemical and mechanical stability [1]. Pyrroles and their derivatives are one of the most important classes of heterocyclic compounds [2]. A four-component coupling reaction (4cr) consisted of aldehydes 1, amines 2, 1, 3 -dicarbonyl compounds 3 and nitromethane 4 afforded substituted pyrroles 5, using MCM-41-SO3H as heterogeneous catalyst. We investigated the synthesis of pyrrole derivatives in the solvent-free conditions. Products were obtained in good yields and short times.