EventsThe 20th International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-20-b004
This submission belongs to the session b. Bioorganic, Medicinal and Natural Products Chemistry of the event The 20th International Electronic Conference on Synthetic Organic Chemistry
Published date
01 Nov, 2016
Citation
Josef Jampilek, Tomas Gonec, Josef Stranik, Jiri Kos, Michal Oravec, Matus Pesko, Katarina Kralova, Preparation and Photosynthesis-Inhibiting Activity of 1-[(2-Nitrophenyl)carbamoyl]naphthalen-2-yl Alkylcarbamates, in Proceedings of The 20th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2016, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-20-b004
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Preparation and Photosynthesis-Inhibiting Activity of 1-[(2-Nitrophenyl)carbamoyl]naphthalen-2-yl Alkylcarbamates

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Josef Jampilek 1
Tomas Gonec 2
Josef Stranik 2
Jiri Kos 2
Michal Oravec 3
Matus Pesko 4
Katarina Kralova 5
1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Comenius University, Odbojarov 10, 83232 Bratislava, Slovakia, Czech Republic
2. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Comenius University, Odbojarov 10, 832 32 Bratislava, Slovakia
3. Global Change Research Institute CAS, Belidla 986/4a, 603 00 Brno, Czech Republic
4. Department of Environmental Ecology, Faculty of Natural Sciences, Comenius University, Mlynska dolina Ch-2, 842 15 Bratislava, Slovakia
5. Institute of Chemistry, Faculty of Natural Sciences, Comenius University, Mlynska dolina Ch-2, 842 15 Bratislava, Slovakia
Abstract

In this study, a series of eight 1-[(2-nitrophenyl)carbamoyl]naphthalen-2-yl alkylcarbamates was prepared and characterized. The discussed compounds were prepared by microwave-assisted and conventional synthesis. The compounds were tested for their activity related to inhibition of photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. The PET-inhibiting activity of the compounds was relatively low; the corresponding IC50 values ranged from 0.233 to 0.487 mmol/L and the highest activity within the series of compounds was observed for 1-[(2-nitrophenyl)carbamoyl]naphthalen-2-yl pentylcarbamate. The compounds were found to inhibit PET in photosystem II.

Keywords
Alkylcarbamates
Hydroxynaphthalene-carboxamides
PET inhibition
Spinach chloroplasts
Structure-activity relationships.
Manuscript
Jampilek_ECSOC-20.pdf
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