Events The 20th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session a. General Organic Synthesis of the event The 20th International Electronic Conference on Synthetic Organic Chemistry

Published date

01 Nov, 2016

Citation

Maryam Karimi, Mohammad Reza Naimi-Jamal, Saeed Farhadi, Synthesis of triazoloquinazolinone derivatives employing Silica-based sulfonic acid (MCM- 41-SO3H): A mild, reusable and highly efficient heterogeneous catalyst, in Proceedings of The 20th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2016, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-20-a005

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Synthesis of triazoloquinazolinone derivatives employing Silica-based sulfonic acid (MCM- 41-SO3H): A mild, reusable and highly efficient heterogeneous catalyst

Mohammad Reza Naimi-Jamal ¹

Maryam Karimi ¹

Saeed Farhadi ¹

1. Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, IRAN.

Abstract

A multicomponent reaction (MCR) can create highly complex molecules from readily available starting materials without the complicated purification operations; thus, MCRs are resource and time-effective and economically favorable processes in diversity generation1. A wide variety of quinazolinone derivatives have been synthesized by condensation of 3-amino- 1, 2, 4-triazole as amine sources, with dimedone and aromatic aldehydes in the presence of 20 mol % of MCM-41-SO3H as effective catalyst in green and reusable catalyst in refluxing DMF conditions through one-pot reactions. Triazoloquinazolinone are important because of their wide range of biological activities, application in medicinal chemistry, pharmaceutical industry and agrochemicals as herbicides and active pharmaceuticals2.

References
1. D. J. Ramon, M. Yus, Angew. Chem. 2005, 44, 1602.
2. V. Haridas, K. Lal, Y. K. Sharma. Tetrahedron Lett. 2007, 48, 4719.

Keywords

triazoloquinazolinone derivatives ,MCM- 41-SO3H

heterogeneous catalyst

Manuscript

Karimi_Maryam_Spania1 - Copy.pdf

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