EventsThe 20th International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-20-a029
This submission belongs to the session a. General Organic Synthesis of the event The 20th International Electronic Conference on Synthetic Organic Chemistry
Published date
01 Nov, 2016
Citation
Alicia E. Cruz-Jiménez, Rocío Gámez-Montaño, Angel Rentería-Gómez, Synthesis of 1,5-disubstituted-1H-tetrazole methane-linked bis-heterocycles via Ugi-azide, in Proceedings of The 20th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2016, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-20-a029
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Synthesis of 1,5-disubstituted-1H-tetrazole methane-linked bis-heterocycles via Ugi-azide

Alicia E. Cruz-Jiménez 1
Angel Rentería-Gómez 1
Rocío Gámez-Montaño 1
1. Universidad de Guanajuato
Abstract

A series of twelve new 1,5-disubstituted-1H-tetrazoles were synthesized via Ugi-azide. The products were synthesized in moderate to excellent yields (50-96%). Methane-linked bis-heterocycles play a relevant role in medicinal chemistry. Tetrazole and furan heterocyclic moieties are present in many drugs. It has been well documented that both moieties could improve parameters of bioactive products such as bioavailability, lipophilicity and metabolic resistance.

Keywords
Ugi-azide
Tetrazoles
Furans
bis-heterocycles
MedChem.
Manuscript
ECSOC AECJ-ARG-RGM (paper).pdf
Poster
ECSOC AECJ-ARG-RGM (slides).pdf
ECSOC AECJ-ARG-RGM (slides).pdf
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