New multicomponent approach for the synthesis of coumarin derivatives by using environmental-friendly core/shell nanocatalyst

In this work, a three-component reaction of salicylaldehyde, diethylmalonate and phenylhydrazine in the presence of Fe₃O₄@SiO₂@NH₂ as a core/shell nanocatalyst in EtOH was used to form a novel series of coumarin derivatives. This catalytic protocol was simply carried out in high yields and short reaction times. The remarkable magnetic properties of this nanocomposite provide easy separation of the catalyst from the reaction mixture without considerable loss of activity.