Events The 20th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session a. General Organic Synthesis of the event The 20th International Electronic Conference on Synthetic Organic Chemistry

Published date

01 Nov, 2016

Citation

Eric Deniau, Christophe Michon, Stéphane LEBRUN, Francine Agbossou-Niedercorn, Regioselective organocatalyzed asymmetric bromolactonization of aryl acrylate-type carboxylic acids. A new approach towards enantioenriched 3-substituted isobenzofuranones., in Proceedings of The 20th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2016, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-20-a037

Facebook

Twitter

Regioselective organocatalyzed asymmetric bromolactonization of aryl acrylate-type carboxylic acids. A new approach towards enantioenriched 3-substituted isobenzofuranones.

Eric Deniau ¹

Christophe Michon ²

Stéphane LEBRUN ²

Francine Agbossou-Niedercorn ²

1. Unité de Catalyse et de Chimie du Solide (UCCS) UMR CNRS 8181 - Axe CCM - Equipe CASECO, Fiji

2. Unité de Catalyse et de Chimie du Solide (UCCS) UMR CNRS 8181 - Axe CCM - Equipe CASECO

Abstract

The stereoselective synthesis of a variety of 3-substituted isobenzofuranones has been developed through a new and flexible route. When combined with a catalytic amount of benzoic acid, quinidine thiocarbamate bifunctional catalysts have demonstrated their efficiency for the enantioselective bromolactonization reaction of styrene-type carboxylic acids bearing an alkoxycarbonyl electron withdrawing group on the carbon-carbon double bond.

Keywords

Asymmetric organocatalysis

Cinchona alkaloids

Bromolactonization reaction

3-Substituted isobenzofuranones

Manuscript

ecsoc_Bromolactonization.pdf

Isoquinoline-substituted hybrid compounds: synthesis and computational studies

Graphene-based polymer nanocomposite, a new and efficient catalyst for synthesis of Benzimidazole derivatives