Graphene-based polymer nanocomposite, a new and efficient catalyst for synthesis of Benzimidazole derivatives

Benzimidazole derivatives are among the most significant classes of bioactive molecules in drugs and pharmaceuticals. The construction of these heterocycles has received an increasing attention to synthetic organic chemists and biologists [1]. During recent decades, numerous heterogeneous catalysts have been proposed and employed for constructing the benzimidazole. On the other hand, graphene-based polymer nanocomposites have attracted strong interest due to their novel properties or enhanced performance [2]. In this work, we reported the synthesis of benzimidazole derivatives via the condensation of benzene-1, 2-diamines with benzaldehyde derivatives catalyzed by Graphene-based polymer nanocomposites under mild conditions in moderate to good yields.

References

 [1] Zhan-Hui Zhang, Liang Yin, Yong-Mei Wang, Catalysis Communications, 8, 1126–1131, (2007).

 [2] Li Wang, Xingping Lu, Shengbin Lei, Yonghai Song, Journal of Materials Chemistry A, 2, 4491-4509, (2014).