EventsThe 20th International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-20-a039
This submission belongs to the session a. General Organic Synthesis of the event The 20th International Electronic Conference on Synthetic Organic Chemistry
Published date
01 Nov, 2016
Citation
moghadaseh keshvari, Hossein Ghafuri, Negar Joorabchi, Atefeh Emami, Thiamine: an efficient, biodegradable, green catalyst for one-pot synthesis of functionalized dihydropyridines, in Proceedings of The 20th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2016, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-20-a039
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Thiamine: an efficient, biodegradable, green catalyst for one-pot synthesis of functionalized dihydropyridines

moghadaseh keshvari 1
Hossein Ghafuri 1
Negar Joorabchi 1
Atefeh Emami 1
1. Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, IranUniversity of Science and Technology, P.O. Box 16846-13114 Tehran, I. R. Iran.
Abstract

An efficient protocol was developed for the four component and one-pot synthesis of functionalized 1, 4-dihydropyridines by thiamine (VB1) as biocatalyst via the reaction of malononitrile, substituted aldehydes, dimethylacetylenedicarboxylate and substituted aniline in ethanol at room temperature. Reactions were completed in 80 min. Availability and non-toxicity are the advantages of this green catalyst. Also, easy work-up, no chromatographic purifications and high yields in short reaction time are the advantages of this procedure.

References

[1] Mandhane, P. G., Joshi, R. S., Nagargoje, D. R., Gill, C. H., Chinese Chemical Letters, 22, 563–566, (2011).
[2] Sharma, P., Gupta, M., Journal of Chemical Sciences, 128, 61–65, (2016).

Keywords
1
4-dihydropyridines
Thiamine
Biocatalyst
Manuscript
full text-keshvari.pdf
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