Events The 2nd International Electronic Conference on Medicinal Chemistry and Pharmaceutics

Event submissions

Published

This submission belongs to the session S8. Nanomedicine and Nanotechnology of the event The 2nd International Electronic Conference on Medicinal Chemistry and Pharmaceutics

Published date

28 Oct, 2026

Academic Editor

Francisco Javier Otero Espinar

Contribution&Funding

Conceptualization,

[Maryana Salamah]

Methodology,

[Maryana Salamah]

Software,

[Maryana Salamah]

Validation,

[Maryana Salamah]

Formal analysis,

[Maryana Salamah]

Investigation,

[Maryana Salamah]

Writing - original draft,

[Maryana Salamah]

Writing - review,

[editing] ; [Maryana Salamah]

Visualization,

[Maryana Salamah]

Funding: --

Citation

Maryana Salamah, Gábor Katona, Ildikó Csóka, György Balogh, Preparation and Optimization of Favipiravir-Loaded Chitosomes for Intranasal Administration, in Proceedings of The 2nd International Electronic Conference on Medicinal Chemistry and Pharmaceutics, 1 November–30 November 2026, MDPI: Basel, Switzerland

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$Preparation and Optimization of Favipiravir-Loaded Chitosomes for Intranasal Administration$

Maryana Salamah ^1,2

Gábor Katona ¹

Ildikó Csóka ¹

György Balogh ^3,4

1. Institute of Pharmaceutical Technology and Regulatory Affairs, Faculty of Pharmacy, University of Szeged, Szeged, H-6720 , Hungary

2. Centre of Excellence for Interdisciplinary Research, Development and Innovation, University of Szeged, Szeged, H-6720 , Hungary

3. Department of Pharmaceutical Chemistry, Semmelweis University, Budapest, H-1092 , Hungary

4. Center for Pharmacology and Drug Research & Development, Department of Pharmaceutical Chemistry, Semmelweis University, Budapest, H-1085 , Hungary

Abstract

The aim : This study aimed to prepare and optimize favipiravir-loaded niosomes (FAV-NIOs) for the treatment of neurotropic viruses in CNS, followed by coating with chitosan to prepare FAV-loaded chitosomes (FAV-CS) for intranasal administration to overcome the low solubility and bioavailability of FAV. Methods : FAV-NIOs were prepared using the ethanol injection method [1]. The impact of Span ® 60 amount (X1) and cholesterol amount (X2) on Z-average, Polydispersity index (PDI), zeta potential (ZP) and encapsulation efficiency (EE%) was evaluated using a 3 2 factorial design. After that, different concentrations of chitosan were used to prepare FAV-CS [2]. The optimized formulations were characterized in terms of colloidal properties, mucoadhesive properties, in vitro blood-brain barrier permeability (BBB-PAMPA), in vitro drug release, ex vivo nasal permeability and biopharmaceutical aspects. Results: The optimized formulations; FAV-NIO and FAV-CS-0.5 showed Z-average < 300 nm, PDI < 0.3, ZP > |\pm 30 mV |, and high EE% (> 50%). Both FAV-NIO and FAV-CS-0.5 showed a high interaction with mucin. BBB-PAMPA results showed that FAV-CS-0.5 has significantly higher permeability than FAV-NIO and initial FAV. FAV-CS-0.5 showed a higher release rate in comparison to FAV-NIO and initial FAV. The ex vivo results showed that FAV diffusion from FAV-NIO and FAV-CS-0.5 through the human nasal mucosa was higher than initial FAV. Finally, the biopharmaceutical parameters were significantly improved in both FAV-NIO and FAV-CS-0.5 compared to initial FAV. Conclusion : Utilising niosomes and chitosomes to deliver FAV through intranasal administration could be a promising approach to improve its low bioavailability and therapeutic effect. References : [1] Sita, V. G. et al. Journal of Drug Delivery Science and Technology 2020, 58, 101791. [2] Tulbah, A. S. et al. International Journal of Pharmaceutics: X 2023, 6, 100206

Keywords

Favipiravir

niosomes

chitosomes

mucoadhesion

BBB-PAMPA

ex vivo.

Asymmetric liposomes prepared with a simple cyclodextrin-lipid complex method to improve performance of vesicles beyond conventional liposomes

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