EventsThe 20th International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-20-a042
This submission belongs to the session a. General Organic Synthesis of the event The 20th International Electronic Conference on Synthetic Organic Chemistry
Published date
01 Nov, 2016
Citation
Victor V. Dotsenko, Maksim A. Kolosov, Valeriy D. Orlov, Synthesis of new 4,7-dihydropyrazolo[1,5-a]pyrimidines and 4,5,6,7,8,9-hexahydropyrazolo[5,1-b]quinazolines through the non-catalyzed Biginelli reaction, in Proceedings of The 20th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2016, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-20-a042
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Synthesis of new 4,7-dihydropyrazolo[1,5-a]pyrimidines and 4,5,6,7,8,9-hexahydropyrazolo[5,1-b]quinazolines through the non-catalyzed Biginelli reaction

Maksim A. Kolosov 1
Valeriy D. Orlov 1
Victor V. Dotsenko 2,3,4
1. V.N. Karazin Kharkov National University, 4 Svobody sq., 61022 Kharkov, Ukraine
2. Kuban State University, 149 Stavropolskaya Str., Krasnodar 350040, Russian Federation
3. ChemEx Lab, Vladimir Dal’ Lugansk National University, Lugansk, 91034 Russia.
4. North-Caucasus Federal University, 1 Pushkina St., 355009 Stavropol, Russian Federation
Abstract

The Biginelli-type reactions of 5-amino-3-arylpyrazole-4-carbonitriles with aldehydes and 1,3-dicarbonyl compounds were studied in details. New pyrazolopyrimidines and pyrazoloquinazolines were synthesized through the reaction of 5-amino-3-arylpyrazole-4-carbonitriles with aromatic aldehydes and active 1,3-dicarbonyls (acetyl acetone, acetoacetanilides or dimedone) in the boiling DMF. The reaction requires no catalysts.

Keywords
Biginelli reaction
uncatalyzed reactions
pyrazolo[1,5-a]pyrimidines
pyrazolo[5,1-b]quinazolines
Manuscript
ecsoc20 2 kolosov.pdf
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