EventsThe 2nd International Electronic Conference on Medicinal Chemistry and Pharmaceutics
Event submissions
Published
This submission belongs to the session S9. Formulation, Drug Delivery, and Controlled Release of the event The 2nd International Electronic Conference on Medicinal Chemistry and Pharmaceutics
Published date
28 Oct, 2026
Academic Editor
author-avatarThierry Vandamme
Contribution&Funding
Conceptualization,
[Marwa Hamdy Sayed Dawoud] ; [Nabila Mohamed Sweed]
Methodology,
[Marwa Hamdy Sayed Dawoud] ; [Salma Essam Ali Hassan ] ; [Nawal Medhat Abdelrahman] ; [Islam Mohamed Salaheldin Mannaa ] ; [Verina Sameh Edward] ; [Miriam Magdy Kamal Sedhom] ; [Motaz Mohamed Abdelah Mohamed Ali Abouelkher ] ; [Farida Waheed Afifi Mohamed Hilal ] ; [Nabila Mohamed Sweed] ; [Jessica Cherif Demian] ; [Mariam maged youssef] ; [Farida Ahmed Salaheldin ] ; [Mariam Mohamed Fathy]
Software,
[Nabila Mohamed Sweed] ; [Marwa Hamdy Sayed Dawoud] ; [Islam Mohamed Salaheldin Mannaa ]
Validation,
[Salma Essam Ali Hassan ] ; [Nabila Mohamed Sweed] ; [Marwa Hamdy Sayed Dawoud] ; [Islam Mohamed Salaheldin Mannaa ]
Formal analysis,
[Verina Sameh Edward] ; [Salma Essam Ali Hassan ] ; [Nawal Medhat Abdelrahman] ; [Islam Mohamed Salaheldin Mannaa ] ; [Marwa Hamdy Sayed Dawoud] ; [Mariam Mohamed Fathy] ; [Jessica Cherif Demian] ; [Miriam Magdy Kamal Sedhom] ; [Farida Ahmed Salaheldin ] ; [Motaz Mohamed Abdelah Mohamed Ali Abouelkher ] ; [Farida Waheed Afifi Mohamed Hilal ] ; [Nabila Mohamed Sweed] ; [Mariam maged youssef]
Investigation,
[Salma Essam Ali Hassan ] ; [Nabila Mohamed Sweed] ; [Islam Mohamed Salaheldin Mannaa ] ; [Marwa Hamdy Sayed Dawoud]
Resources,
[Islam Mohamed Salaheldin Mannaa ] ; [Marwa Hamdy Sayed Dawoud] ; [Nabila Mohamed Sweed]
Data curation,
[Miriam Magdy Kamal Sedhom] ; [Marwa Hamdy Sayed Dawoud] ; [Nabila Mohamed Sweed] ; [Verina Sameh Edward] ; [Nawal Medhat Abdelrahman] ; [Islam Mohamed Salaheldin Mannaa ]
Writing - original draft,
[Motaz Mohamed Abdelah Mohamed Ali Abouelkher ] ; [Farida Waheed Afifi Mohamed Hilal ] ; [Nabila Mohamed Sweed] ; [Mariam maged youssef] ; [Miriam Magdy Kamal Sedhom] ; [Jessica Cherif Demian] ; [Marwa Hamdy Sayed Dawoud] ; [Farida Ahmed Salaheldin ] ; [Verina Sameh Edward] ; [Nawal Medhat Abdelrahman] ; [Salma Essam Ali Hassan ] ; [Islam Mohamed Salaheldin Mannaa ] ; [Mariam Mohamed Fathy]
Writing - review,
[editing] ; [Farida Ahmed Salaheldin ] ; [Mariam maged youssef] ; [Marwa Hamdy Sayed Dawoud] ; [Jessica Cherif Demian] ; [Mariam Mohamed Fathy] ; [Farida Waheed Afifi Mohamed Hilal ] ; [Motaz Mohamed Abdelah Mohamed Ali Abouelkher ] ; [Nabila Mohamed Sweed] ; [Islam Mohamed Salaheldin Mannaa ]
Visualization,
[Marwa Hamdy Sayed Dawoud] ; [Nabila Mohamed Sweed]
Supervision,
[Marwa Hamdy Sayed Dawoud] ; [Verina Sameh Edward] ; [Nabila Mohamed Sweed] ; [Nawal Medhat Abdelrahman] ; [Islam Mohamed Salaheldin Mannaa ]
Project administration,
[Marwa Hamdy Sayed Dawoud] ; [Nabila Mohamed Sweed]
Funding: --
Citation
Marwa Hamdy Sayed Dawoud, Nabila Mohamed Sweed, Islam Mohamed Salaheldin Mannaa , Salma Essam Ali Hassan , Nawal Medhat Abdelrahman, Verina Sameh Edward, Miriam Magdy Kamal Sedhom, Motaz Mohamed Abdelah Mohamed Ali Abouelkher , Farida Waheed Afifi Mohamed Hilal , Jessica Cherif Demian, Mariam maged youssef, Farida Ahmed Salaheldin , Mariam Mohamed Fathy, Smart Dual-Coated Polymersomes for Colon-Targeted Delivery of Repurposed Vardenafil in Ulcerative Colitis, in Proceedings of The 2nd International Electronic Conference on Medicinal Chemistry and Pharmaceutics, 1 November–30 November 2026, MDPI: Basel, Switzerland
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Smart Dual-Coated Polymersomes for Colon-Targeted Delivery of Repurposed Vardenafil in Ulcerative Colitis

Marwa Hamdy Sayed Dawoud 1
Nabila Mohamed Sweed 2
Islam Mohamed Salaheldin Mannaa 1
Salma Essam Ali Hassan 1
Nawal Medhat Abdelrahman 1
Verina Sameh Edward 1
Miriam Magdy Kamal Sedhom 1
Motaz Mohamed Abdelah Mohamed Ali Abouelkher 1
Farida Waheed Afifi Mohamed Hilal 1
Jessica Cherif Demian 1
Mariam maged youssef 1
Farida Ahmed Salaheldin 1
Mariam Mohamed Fathy 1
1. Pharmaceutics, MSA University (October University for Modern Sciences and Arts), Giza, 12451, Egypt
2. Pharmacetics, MSA University (October University for Modern Sciences and Arts), Giza, 12451, Egypt
Abstract

Background:
Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by recurrent colonic inflammation and substantial morbidity. Effective management requires drug delivery that targets the colon while limiting premature release in the upper gastrointestinal tract. Vardenafil, a phosphodiesterase-5 inhibitor with reported anti-inflammatory activity, is a promising repurposed candidate for UC; however, its poor aqueous solubility and limited bioavailability may restrict therapeutic usefulness. Nanocarrier-based systems can improve drug incorporation, protect the drug during gastrointestinal transit, and enhance colonic localization.

Aim:
This study aimed to develop, optimize, and dual-coat vardenafil-loaded PLGA polymersomes with chitosan and Eudragit S100 to provide sequential mucoadhesive, pH-responsive, and microbiota-responsive delivery to the colon.

Methods:
Vardenafil-loaded PLGA polymersomes were prepared by emulsion solvent evaporation. A response surface design optimized the polymersomes in terms of the particle size and the entrapment efficiency. The optimized polymersomes were further coated with chitosan and Eudragit S100, then characterized for particle size, polydispersity index, zeta potential, and entrapment efficiency. The optimized dual-coated formulation was evaluated for in-vitro release, mucoadhesion, and pharmacokinetic performance.

Results:
The optimized system formed dual-coated nanoparticles with a particle size of 206.17 ± 12.6 nm, PDI of 0.29 ± 0.01, zeta potential of +49.65 ± 9.54 mV, and entrapment efficiency of 70.43% ± 7.41. Drug release was limited in simulated gastric and intestinal fluids, with 19.8% ± 1.8 released within 5 h, followed by sustained release reaching 97.7% ± 2.8 after 24 h in simulated colonic fluid. Mucin interaction increased particle size 5.32-fold, indicating mucoadhesion. Compared with standard vardenafil, the nanoparticle formulation increased relative bioavailability 3.52-fold and prolonged residence time 7.19-fold.

Conclusion:
Chitosan/Eudragit S100 dual-coated PLGA polymersomes provide a promising platform for colon-targeted vardenafil delivery. Their sequential coating combines mucoadhesive, pH-responsive, and microbiota-responsive properties, improving controlled release, and residence time, and supporting further investigation for UC therapy.

Keywords
Keywords: Ulcerative colitis; Vardenafil; Polymersomes; Colon-targeted drug delivery; Dual-coating nanocarriers.
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