Events The 2nd International Electronic Conference on Medicinal Chemistry and Pharmaceutics

Event submissions

Published

This submission belongs to the session S9. Formulation, Drug Delivery, and Controlled Release of the event The 2nd International Electronic Conference on Medicinal Chemistry and Pharmaceutics

Published date

28 Oct, 2026

Academic Editor

Alfredo Berzal-Herranz

Citation

Brenda López, Daylenis Pérez, Luisbel González, Alginate hydrogels with reduced graphene oxide and condensed tannins: formulation programs polyphenol release for wound management, in Proceedings of The 2nd International Electronic Conference on Medicinal Chemistry and Pharmaceutics, 1 November–30 November 2026, MDPI: Basel, Switzerland

Facebook

Twitter

$Alginate hydrogels with reduced graphene oxide and condensed tannins: formulation programs polyphenol release for wound management$

Brenda López ^1,2

Daylenis Pérez ³

Luisbel González ²

1. Institute of Applied Sciences, Universidad Autónoma de Chile, Santiago, Chile

2. Instituto de Ciencias Aplicadas, Facultad de Ingeniería, Universidad Autónoma de Chile, Santiago, Chile

3. Laboratorio de Biomateriales, Departamento de Ingeniería Química, Facultad de Ingeniería, Universidad de Concepción, Concepción, Chile

Abstract

Wound repair requires dressings that deliver bioactive agents in a sustained manner. To this end, borate-crosslinked alginate hydrogels were formulated to carry condensed tannins (TA) from *Pinus radiata* bark, with dopamine-reduced graphene oxide (rGO) as a network modulator. Nine formulations were prepared by combining three rGO and three TA levels (0, 4.5 and 9 wt%) and subjected to physicochemical characterization, swelling and release in PBS (pH 7.4; 37 °C), antioxidant and antibacterial activity, human fibroblast response and in vivo healing in pigs. The rGO content governed the release mechanism. At 4.5%, a compact, hydrophobic and markedly anionic surface layer was formed (-46.8 mV), with power-law exponents below 0.5, indicative of a sustained release controlled by TA diffusion through the pores of the gel. At 9%, network relaxation dominated: release was exhausted within 80 minutes, delivering only 26.4% of the loaded TA. TA determined the biological performance. It raised swelling to 60% of the weight, which favors exudate absorption, and provided antioxidant capacity (46 mg Trolox equivalents/100 g) and activity against *Escherichia coli* . Fibroblast viability reached 145% of the control, indicating that the material stimulates proliferation. In vivo, Alg/rGO9/TA9, the most heavily loaded formulation, closed the wound by day 21, suggesting that its rapid release concentrates antioxidant and antibacterial action in the early inflammatory phase. Overall, rGO loading makes it possible to program polyphenol release in bioactive dressings.

Keywords

Alginate hydrogels; condensed tannins; reduced graphene oxide; controlled release; bioactive dressings; wound healing

Poster

Poster_ECMC-P2026_Sciforum-210347_Lopez.pdf

Influence of thermal treatment on doxycycline release from clinoptilolite-rich natural zeolite carriers

Development and Optimization of a Green Co-Processed Orange Peel Pectin-Flaxseed Mucilage Carrier for Solubility and Dissolution Enhancement of Candesartan Cilexetil