Events The 20th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session a. General Organic Synthesis of the event The 20th International Electronic Conference on Synthetic Organic Chemistry

Published date

01 Nov, 2016

Citation

Mohamed Ould M'hamed, Saad H. Al Qahtani, Green and efficient technique for the three component synthesis of 2-aminothiophenes using ball-milling method through Gewald reaction., in Proceedings of The 20th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2016, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-20-a050

Facebook

Twitter

Green and efficient technique for the three component synthesis of 2-aminothiophenes using ball-milling method through Gewald reaction.

Mohamed Ould M'hamed ¹

Saad H. Al Qahtani ²

1. AL-Imame university, Saudi Arabia

2. AL-Imame university

Abstract

In this paper, a simple, green, and efficient approach was used to the synthesis of various 2-aminothiophenes derivatives with excellent yields (97%) in a short reaction time under ball milling technique without any solvent and any catalyst through Gewald reaction. A direct condensation of an equimolar amount of an ethyl acetoacetate/acetyl acetone, malononitrile/ethyl cynoacetate, and elemental sulfur under ball milling offered 2-aminothiophenes derivatives in 30 min at 750 rpm.

Keywords

Ball milling

2-aminothiophene derivatives

Gewald reaction.

Manuscript

E-Organic Mohamed.pdf

Quantum chemical modeling of the olefin oxidation by aromatic nitrocompounds in the triplet state

Organoselenium compounds, an overview on the biological activities beyond antioxidant properties