Reaction of 2-hydroxy-N^`-[(4-oxo-4H-chromen-3-yl)methylidene]benzohydrazide with some phosphorus reagents: Synthesis and evaluation of anticancer activities of some novel α-hydrazinophosphonic acid, 1,4,5,2-oxadiazaphosphinines and 1,3,2-benzoxaza-phosphinines bearing a chromone ring.

Some novel 1,4,5,2-oxadiazaphosphinines, 1,3,2-benzoxazaphosphinines and α-hydrazino-phosphonic acid bearing a chromone ring have been obtained from reaction of 2-hydroxy-N^`-[(4-oxo-4H-chromen-3-yl)methylidene]benzohydrazide (2) with some phosphorus reagents such as phosphonic acid and its diesters, phosphorus sulfides and phosphorus halides in dry dioxane. The compounds were evaluated for their anticancer activities and on the expression of VEGF inhibition. Among the synthesized compounds, compounds 3 and 7 exhibited high effect against breast cancer cells MCF-7 in comparison with the standard drug and on the expression of VEGF inhibition.