Gate valves are essential components in industrial fluid control systems, but the hermetic sealing elements of these valves face severe tribological challenges. Continuous friction and wear at the gate–seat interface can degrade sealing performance, increase actuation force requirements, and eventually cause leakage or failure, especially under high-pressure or corrosive conditions. This paper addresses the need for improved tribological performance of gate valve hermetic elements by exploring advancements in materials, surface engineering, and design optimization. The article presents a combined approach employing both experimental tribological testing and computational analysis to evaluate friction and wear behavior of various sealing material pairs, coatings, and surface treatments under simulated valve operating conditions. Key parameters such as friction coefficient, wear rate, and microstructural integrity were measured across different lubrication regimes and operational environments. The results demonstrate that incorporating advanced wear-resistant coatings (hardfacing or ceramic-based coatings) and optimized sealing surface geometry significantly reduce frictional losses and mitigate wear at the gate–seat interface. Enhanced material combinations, including high-hardness alloys and self-lubricating composites, showed up to notable improvements in wear resistance and maintained reliable sealing under extreme pressures and corrosive media. These tribology-driven developments contribute to extended valve service life and more stable leak-tight performance. The findings offer practical guidelines for designers and engineers to improve gate valve reliability, reduce maintenance needs, and ensure safer operation in demanding industrial applications.