Alternative Methodologies for the Synthesis of Substituted 3-arylcoumarins: Perkin Reactions and Palladium-Catalyzed Synthesis

With the aim to find out the best methodology to prepare different series of substituted coumarins, thinking on their pharmacological evaluation, in the present communication we report the synthesis of 3-phenylcoumarin with different number and position of substituent groups in both 3-phenyl and coumarin rings. The substituents in this new scaffold were introduced in the 6 and 8 positions of the coumarin moiety and in 3'and 4' positions of the 3-phenyl ring. The synthesized compounds 1-7, 8 and 9-11 were prepared and characterized by different methodologies. Perkin modified reaction (method A and B) and Palladium-catalyzed synthesis (method C) were the methodologies described in this communication.