Events The 14th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session a. General Organic Synthesis of the event The 14th International Electronic Conference on Synthetic Organic Chemistry

Published date

21 Oct, 2010

Citation

Eugenio Uriarte, Lourdes Santana, Giovanna Delogu, Maria Joao Matos, Silvia Serra, Synthesis of New Possible Monoamine Oxidase Inhibitors, in Proceedings of The 14th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2010, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-14-00378

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Synthesis of New Possible Monoamine Oxidase Inhibitors

Eugenio Uriarte ¹

Lourdes Santana ¹

Giovanna Delogu ²

Maria Joao Matos ¹

Silvia Serra ^1,2

1. Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain

2. Department Farmaco Chimico Tecnologico, Facoltà di Farmacia, Università Degli Studi di Cagliari, Cagliari 09124, Italy.

Abstract

We have generated different resveratrol-coumarin hybrids with the aim of evaluate their biological applications and their pharmacological properties, particularly the inhibitory activity of monoamine oxidase enzyme. According to that, a first series of 3-aryl-4-hydroxycoumarins has been synthesized starting from aryl boronic acids and phenyliodonium zwitterions precursors by a palladium-catalyzed coupling reaction.

Keywords

Coumarins

MAO

Suzuki reaction

Alternative Methodologies for the Synthesis of Substituted 3-arylcoumarins: Perkin Reactions and Palladium-Catalyzed Synthesis

Bicyclic Allyltin Derivatives through Selective "One Pot" Hydrostannation-Diels Alder Reaction