EventsThe 14th International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-14-00410
This submission belongs to the session a. General Organic Synthesis of the event The 14th International Electronic Conference on Synthetic Organic Chemistry
Published date
20 Oct, 2010
Citation
Pierre Grandclaudon, Eric Deniau, Axel Couture, Vangelis Agouridas, Magali Lorion, Synthesis and Cytotoxic Evaluation of Constrained Analogues of Combretastatin and Combretastatin A4., in Proceedings of The 14th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2010, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-14-00410
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Synthesis and Cytotoxic Evaluation of Constrained Analogues of Combretastatin and Combretastatin A4.

Pierre Grandclaudon 1,2,3
Eric Deniau 1,2,3
Axel Couture 1,2,3
Vangelis Agouridas 1,2,3
Magali Lorion 1,2,3
1. Université Lille Nord de France, F-59000 Lille, France
2. USTL, Laboratoire de Chimie Organique Physique, EA CMF 4478, Bâtiment C3(2), F-59655 Villeneuve d'Ascq, France
3. CNRS, UMR 8181 'UCCS', F-59655 Villeneuve d'Ascq, France
Abstract
A series of cis-locked stilbenic compounds related to combretastatin and combretastatin A4 has been designed and synthesized. The cytotoxic effects of these rigid analogues were evaluated as well as their abilities to inhibit tubulin polymerization.
Keywords
combretastatins
isoindolinones
oxygen heterocycle
oxidation
anticancer agents.
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