Events The 14th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session b. Natural Products Chemistry of the event The 14th International Electronic Conference on Synthetic Organic Chemistry

Published date

20 Oct, 2010

Citation

Zahra Mokhtari, Mohammad G. Dekamin, Highly Efficient Three-Component Strecker-Type Reaction of Aldehydes and Ketones Using TMSCN Catatalyzed by Recyclable and Heterogeneous Mesoporous B-MCM-41, in Proceedings of The 14th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2010, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-14-00412

Facebook

Twitter

Highly Efficient Three-Component Strecker-Type Reaction of Aldehydes and Ketones Using TMSCN Catatalyzed by Recyclable and Heterogeneous Mesoporous B-MCM-41

Zahra Mokhtari ¹

Mohammad G. Dekamin ¹

1. Pharmaceutical and Biologically-Active Compounds Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran 16846-13114, Iran

Abstract

Mesoporous Borosilicate (B-MCM-41) efficiently catalyzed the three-component Strecker-type reaction of different amines and aldehydes or ketones with trimethylsilyl cyanide (TMSCN) in CH₂Cl₂ at room temperature to afford the corresponding α-aminonitriles in excellent yields. The catalyst can be recovered and reuse for at least 5 reaction cycles without significant lose of its reactivity.

Keywords

Carbonyl Compounds

Amine

Trimethylsilyl Cyanide (TMSCN)

α-Aminonitriles

Mesoporous Materials

Cycloaddition of Methyl Acrylate with Substituted Pyridinium-3-olates and Pyrazinium-3-olates: 1,3-Dipolar Cycloaddition versus Diels-Alder

Novel quinazolinone derivatives: Synthesis and Antimicrobial Activity