Events The 14th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session a. General Organic Synthesis of the event The 14th International Electronic Conference on Synthetic Organic Chemistry

Published date

31 Oct, 2010

Citation

J. Gonda, M. Martinková, D. Maliňák, Preparation of (5S)-5-C-methyl-β-L-lyxo-hexofuranose derivative as(+)-lactacystin precursors, in Proceedings of The 14th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2010, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-14-00420

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Preparation of (5S)-5-C-methyl-β-L-lyxo-hexofuranose derivative as(+)-lactacystin precursors

J. Gonda ¹

M. Martinková ¹

D. Maliňák ¹

1. Department of Organic Chemistry, Institute of Chemical Science, Faculty of Science, P.J. Šafárik University in Košice, Moyzesova 11., 040 67, Košice, Slovakia

Abstract

We present here the preparation of the precursor for stereoselective synthesis of (+)-lactacystin starting from D-glucose. The first step is conversion of D-glucose to 1,2:5,6-di-O-isopropylidene-α-D-gulofuranose. The second step is introduction of a methyl group at C5 and preparation of compound 9. This compound can be used as a precursor of target molecule of (+)-lactacystin

Keywords

Lactacystin

Asymetric synthesis

Proteasome inhibitor

Synthesis and Thymidine Phosphorylase Inhibition Evaluation of Pyrazolo[2,3-a]-1,3,5-triazines

Co-crystal Screening Study of Risedronate and Unsubstituted Hexoses