Events The 14th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session d. Polymer Chemistry of the event The 14th International Electronic Conference on Synthetic Organic Chemistry

Published date

30 Oct, 2010

Citation

A. Cepeda, C. Fente, A. Martin-Esteban, R. Barreiro, M. Díaz-Bao, P. Regal, Tuning of a MISPE procedure for the simultaneous extraction of Dexamethasone and Betamethasone, in Proceedings of The 14th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2010, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-14-00422

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Tuning of a MISPE procedure for the simultaneous extraction of Dexamethasone and Betamethasone

A. Cepeda ¹

C. Fente ¹

A. Martin-Esteban ²

R. Barreiro ¹

M. Díaz-Bao ¹

P. Regal ¹

1. Laboratorio de Higiene e Inspección de Alimentos, Facultad de Veterinaria, Lugo (Spain)

2. Departamento de Medio Ambiente, INIA, Madrid (Spain)

Abstract

A molecularly imprinted solid-phase extraction (MISPE) procedure based on precipitation polymerization was developed for the simultaneous extraction of dexamethasone (DM) and its structural isomer, betamethasone (BM), from biological matrices. A DM-imprinted polymer was synthetized using methacrylic acid as monomer and divinylbenzene as cross-linker, and the porogen was a mixture of acetonitrile and toluene (3:1). After removal of the template, loading, washing and elution steps were optimized. The maximun recovery of DM and BM was achieved when loading with toluene and washing with 5% acetonitrile in toluene, and eluting with 1% acetic acid in methanol.

Keywords

Co-crystal Screening Study of Risedronate and Unsubstituted Hexoses

Per–O–acetyl Lactosyl Isothiourea Derivatives: Synthesis and Antimicrobial Activities