Events The 14th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session b. Natural Products Chemistry of the event The 14th International Electronic Conference on Synthetic Organic Chemistry

Published date

31 Oct, 2010

Citation

Shirish P. Deshmukh, Dattatraya V. Mangte, Anvita S. Dandale, Per–O–acetyl Lactosyl Isothiourea Derivatives: Synthesis and Antimicrobial Activities, in Proceedings of The 14th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2010, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-14-00423

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Per–O–acetyl Lactosyl Isothiourea Derivatives: Synthesis and Antimicrobial Activities

Shirish P. Deshmukh ¹

Dattatraya V. Mangte ¹

Anvita S. Dandale ²

1. P. G. Department of Chemistry, Shri Shivaji College, Akola–444001, MS, India.

2. Dept. of Applied Chemistry, Faculty of Tech. & Engg., The M. S. University of Baroda, Vadodara–390001, Gujarat, India.

Abstract

Glycosyl (iso) thioureas being an important intermediate in the synthesis of thioureido carbohydrates herein we reported the synthesis of per–O–acetyl lactosyl aryl isodithiobiuret derivatives. These compounds were synthesized by nucleophilic addition of per-O-acetyl lactosyl aryl isothiourea to tolyl isothiocyanate. Structures of these compounds were confirmed on the basis of IR, HNMR, Mass spectra and elemental analysis. These compounds were also screened for their in vitro antimicrobial activities against bacteria S. aureus, E. coli, P. vulgaris, P. aeruginosa and fungi A. niger, Penicillium.

Keywords

Lactosyl isothioureas

isodithiobiurets

Synthesis

Antibacterial

Antifungal activity

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