Events The 14th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session b. Natural Products Chemistry of the event The 14th International Electronic Conference on Synthetic Organic Chemistry

Published date

31 Oct, 2010

Citation

Paul W. Groundwater, Mark Gray, Sanjib Bhakt, Juan David Guzman, J. Jonathan Harburn, Suresh K. Kottakot, Synthesis of 20-N-Methylpurpuramine E, an Antitubercural Metabolite from Pseudoceratina sponge, in Proceedings of The 14th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2010, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-14-00430

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Synthesis of 20-N-Methylpurpuramine E, an Antitubercural Metabolite from Pseudoceratina sponge

Paul W. Groundwater ¹

Mark Gray ²

Sanjib Bhakt ³

Juan David Guzman ³

J. Jonathan Harburn ²

Suresh K. Kottakot ²

1. Faculty of Pharmacy, The University of Sydney, Sydney, NSW 2006, Australia

2. Sunderland Pharmacy School, University of Sunderland, Wharncliffe Street, Sunderland, SR1 3SD, UK

3. Department of Biological Sciences, Institute of Structural and Molecular Biology, Birkbeck, University of London, Malet Street, Bloomsbury London, WC1E 7HX, UK

Abstract

0-N-Methylpurpuramine E has been successfully synthesized in 2 steps in good yield from readily available starting materials. Structural elucidation has been confirmed through direct comparison with spectroscopic data of isolated natural product.20-N-Methylpurpuramine E has been shown to have MIC = 5 μg mL^-1 against Mycobacterium bovis.

Keywords

marine sponge metabolites

bromotyramine

bromotyrosine

antituberclar

Synthesis and Characterization of Photomodulable Amphiphiles

A new catalyst-free microwave-assisted one-pot four-component synthesis of 1,4-dihydroquinolines in aqueous media