EventsThe 14th International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-14-00446
This submission belongs to the session a. General Organic Synthesis of the event The 14th International Electronic Conference on Synthetic Organic Chemistry
Published date
30 Oct, 2010
Citation
Neda Nazary, Mohammad G. Dekamin, Synthesis of Acetaminophen by Liquid Phase Beckmann Rearrangement of 4-Hydroxyacetophenone Oxime over Nano-Ordered Zn-MCM-41, in Proceedings of The 14th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2010, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-14-00446
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Synthesis of Acetaminophen by Liquid Phase Beckmann Rearrangement of 4-Hydroxyacetophenone Oxime over Nano-Ordered Zn-MCM-41

Neda Nazary 1
Mohammad G. Dekamin 1
1. Pharmaceutical and Biologically-Active Compounds Research Laboratory, Department of chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran
Abstract
Nano-OrderedZn-MCM-41 materials were synthesized using different zinc sources and applied for liquid phase Beckman rearrangement of 4-hydroxyacetophenone oxime to acetaminophen. The reaction conditions such as amount of the catalyst and solvent were optimized to afford acetaminophen in high yields. it Aprotic solvents with high dielectric constant are preferred for this transformation.
Keywords
Acetaminophen
Beckmann Rearrangement
4-Hydroxyacetophenone Oxime
Zn-MCM-41
Nano-Ordered Catalyst.
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