EventsThe 14th International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-14-00455
This submission belongs to the session a. General Organic Synthesis of the event The 14th International Electronic Conference on Synthetic Organic Chemistry
Published date
30 Oct, 2010
Citation
Shahrara Afshar, Heshmatollah Ebraimi Najafabadi, Mansoor Amani, Optimization of synthesis of dioctyl phthalate using response surface methodology, in Proceedings of The 14th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2010, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-14-00455
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Optimization of synthesis of dioctyl phthalate using response surface methodology

Shahrara Afshar 1
Heshmatollah Ebraimi Najafabadi 2
Mansoor Amani 1
1. College of Chemistry, Iran University of Science and Technology, Tehran 16846-13114, Iran
2. Department of Chemistry, Sharif University of Technology, P.O. Box 11155-3516, Tehran, Iran
Abstract
Esterification reaction of phthalic anhydride with 2-ethyl hexanol was investigated using sulfated titanium dioxide nano catalyst. The influence of reaction time, catalyst amount and alcohol/anhydride molar ratio was studied using a rotatable central composite design (CCD). The optimum values of factors were: 83 min for the time, 9 %wt catalyst, 9:1 alcohol:anhydride molar ratio. The maximum yield of 93% at optimum conditions was obtained.
Keywords
Optimization
Response surface methodology
Esterification
Dioctyl phthalate
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