EventsMOL2NET'17, Conference on Molecular, Biomed., Comput. & Network Science and Engineering, 3rd ed.
Event submissions
Published
with-doi10.3390/mol2net-03-04607
This submission belongs to the session 05. NANOBIOMAT-03: Nanotechnology & Biomaterials Sci. Congress, Jackson & Fargo, USA, 2017 of the event MOL2NET'17, Conference on Molecular, Biomed., Comput. & Network Science and Engineering, 3rd ed.
Published date
16 Sep, 2017
Citation
Luciane C. Alberici, Michael González-Durruthy, Zeeki Naal, Carlos Curti, Yosberto Cardenas, Jose M. Monserrat, CNT Mitoprotective activity in mitochondrial swelling, in Proceedings of MOL2NET'17, Conference on Molecular, Biomed., Comput. & Network Science and Engineering, 3rd ed., 15 January–15 December 2017, MDPI: Basel, Switzerland, doi: 10.3390/mol2net-03-04607
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CNT Mitoprotective activity in mitochondrial swelling

Michael González-Durruthy 1
Zeeki Naal 2
Luciane C. Alberici 2
Carlos Curti 2
Yosberto Cardenas 3
image
Jose M. Monserrat 4
1. Institute of Biological Science (ICB), Universidade Federal do Rio Grande (FURG), 90610-000, Porto Alegre, RS, Brazil. E
2. Department of Physic-Chemistry, Faculty of Pharmacy of Ribeirao Preto, University of Sao Paulo (USP), 14040-903 Ribeir˜ao Preto, SP, Brazil.
3. Departamento de Microbiologia, Facultad de Biología, Universidad de La Habana (UH), La Habana, Cuba.
4. Institute of Biological Science (ICB), Universidade Federal do Rio Grande (FURG), 90610-000, Porto Alegre, RS, Brazil.
Abstract

We used different experimental protocols to determine the mitoprotective activity (%P) of different carbon nanotubes (CNT) against mitochondrial swelling. The experimental conditions were combinations of the following factors:  different mitochondrial swelling assays using the MPT-inductor (Ca2+, Fe3+, H2O2) combined or not with a second MPT-inductor and swelling control assays using MPT-inhibitor (CsA, RR, EGTA), exposure time (0–600 s), and CNT concentrations (0–5 mg ml[1]1). Other factors changed were the CNT structural parameters CNT type (SW, SW + DW, MW), CNT functionalization type (H, OH, COOH). We also changed different physico-chemical properties of CNT properties like molecular weight/functionalization ratio (minW/maxW) or maximal and minimal diameter (Dmin/Dmax). Full paper published in: RSC Adv., 2015, 5, 103229–103245

Keywords
Carbon Naotubes
Toxicity
Mitochondrial swelling
Poster
MOL2NET CNT Durruthy.pdf
MOL2NET CNT Durruthy.pdf
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