Synthesis of New Derivatives of Monoazaphenothiazine via Tandem Catalysis

Abstract                                                                                                                                                                                                                                                                                                            The synthesis of new linear monoazaphenothiazine and its substituted derivatives via nickel catalyzed amidation reaction is reported. This was achieved by the condensation of 2-aminothiophenol and 2,3,5-trichloropyridine in aqueous basic medium to produce a new heterocyclic ring, 3-chloro-1-azaphenothiazine. Upon applying, Buchwald–Hartwig Cross coupling reaction, it leads to the syntheses of an array of new 3-amido derivatives which were obtained in good yields. The structures of the synthesized compounds were established based on their analytical and spectra data.