EventsThe 21st International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-21-04723
This submission belongs to the session D. Polymer and Supramolecular Chemistry of the event The 21st International Electronic Conference on Synthetic Organic Chemistry
Published date
03 Nov, 2017
Citation
Kamran Kazemi, Hanieh Rezazadeh, Amir Reza Fareghi, Peyman Najafi Moghadam, Preparation of a New Magnetic Drug Carrier Based on Poly(vinyl alcohol): Synthesis, Characterization, and Drug Release Studies, in Proceedings of The 21st International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2017, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-21-04723
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Preparation of a New Magnetic Drug Carrier Based on Poly(vinyl alcohol): Synthesis, Characterization, and Drug Release Studies

Kamran Kazemi 1
Hanieh Rezazadeh 1
Amir Reza Fareghi 1
Peyman Najafi Moghadam 1
1. Department of Chemistry, Faculty of Science, Urmia University, Urmia, Iran
Abstract

In this study, poly(vinyl alcohol) (PVA) as a biodegradable and biocompatible polymer was modified for use as drug delivery carrier. In the first step, PVA was modified by APTES and then underwent crosslinking using 1,2-dichloroethane. On the other hand, Fe3O4 magnetic nanoparticles (MNPs) were reacted with TEOS and modified with hexamethylene diisocyanate. The modified MNPs were reacted with the free hydroxyl groups of the crosslinked PVA to obtain the final magnetic carrier. A template drug was used in order to study the drug release ability of the prepared carrier. The carrier was also characterized using different analyses such as FT-IR, VSM techniques.

Keywords
Poly(vinyl alcohol)
Magnetic nano-particles
Drug delivery
Hydrogel
Manuscript
ECSOC-21.pdf
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