Preparation and characterization of thiosemicarbazone ligands and study of their iron and palladium derivatives

Transition metal complexes are useful in organic synthesis due to the capability of the metal to activate substrates [1-2]; in particular, cyclometallation reactions may lead to novel routes in organic synthesis. Thiosemicarbazones show a high coordinative capacity given that they possess several potential donor atoms through which they can bind to transition metals. In addition, thiosemicarbazones as well as their semicarbazones analogues have considerable biological and pharmacological interest [3] because of their antibacterial, antiviral and antitumor activity. Their derivatives with ferrocenyl phosphines such as 1,1′‑bis(diphenylphosphino)ferroceno (dppf) show a wide range of applications [4].

This communication includes the preparation and characterization of a series of thiosemicarcarbazones and of their organometallic complexes with palladium and iron.

Acknowledgments

We wish to thank the financial support received from the Xunta de Galicia (Galicia, Spain) under the Grupos de Referencia Competitiva Programme Projects GRC2015/009.

References:

[1]- R. N. Prabhu; R. Ramesh, Tetrahedron Lett., 2013, 54, 1120.

[2]- R. N. Prabhu; R. Ramesh, Tetrahedron Lett., 2012, 53, 5961.

[3] S. Cruz; S. Bernés; P. Sharma; R. Vazquez; G. Hernandez; R. Potillo; R. Gutierrez, Appl. Organomet. Chem., 2010, 24, 8.

[4]- A. Togni; T. Hayashi, Ferrocenes, 1995.