Synthesis of bis-heterocycles type spacer containing 1,5-disubstituted-1H-tetrazoles

1,5-Disustituted tetrazoles (1,5-DS-T) are useful heterocyclic moieties present in many bioactive compounds and drugs. Moreover, they are used as bidentate ligands in coordination chemistry, metal-organic framework science, bioimaging, photo-imaging, explosives, propellants, and high energy materials. In this work we report a series of ten new bis-heterocycles type spacer containing 1,5-disubstituted-1H-tetrazoles and furan, synthesized via Ugi-azide (UA) MCR in good to excellent yields (79-99%), using furfuryl amine as constant component and varying the aldehyde and isocyanide components in mild conditions. Additionally, the furan ring present in this bis-heterocycle has great importance in Diels-Alder cycloaddition reaction. As per our knowledge, there are no any previous reported methods available toward bis-heterocycles type spacer via UA.