Preparation and Structural Assessment of Cocrystal Solvates and Cocrystal Salts of 1,3,5-Triazine-2,4,6-triamine with alpha-Hydroxycarboxylic Acids

In the present research, three cocrystals containing 1,3,5-triazine-2,4,6-triamine (melamine, me) were synthesized and characterized. The robustness of the amine-acid supramolecular synthon is discussed in the stoichiometry of the cocrystals of (me)·(H₂ga)·1/2H₂O (I), (me)·(Hme⁺)·(Hma^-)·DMSO·3H₂O (II) and (Hme⁺)·(Hma^-)·diox·2H₂O (III). The abbreviated designations used are glycolic acid (H₂ga), mandelic acid (H₂ma), dimethyl formamide (DMF), dimethyl sulfoxide (DMSO) and 1,4-Dioxane (diox). All the crystalline materials have been characterized by ¹H-NMR, ¹³C-NMR, IR, and X-ray diffraction. The supramolecular assembly of each cocrystal is also analyzed and discussed.