EventsThe 21st International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-21-04812
This submission belongs to the session B. Bioorganic, Medicinal and Natural Products Chemistry of the event The 21st International Electronic Conference on Synthetic Organic Chemistry
Published date
03 Nov, 2017
Citation
Dong-Jun Fu, Industrial Method for preparing 3-​chloromethyl oxacephem antibiotic nucleus, in Proceedings of The 21st International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2017, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-21-04812
Share
Email
Facebook
Twitter
LinkedIn

Industrial Method for preparing 3-​chloromethyl oxacephem antibiotic nucleus

Dong-Jun Fu 1
1. New Drug Research & Development Center, Zhengzhou University, Zhengzhou 450001, China
Abstract

3-​Chloromethyl oxacephem as a 5-oxa-1-azabicyclo[4.2.0]oct-2-en-8-one heterocycle displayed the potent antibacterial activity against both Gram-positive and Gram-negative bacteria. Importantly, it can be used as a starting material to synthesize Latamoxef and Flomoxef. However, the industrial route of 3-​chloromethyl oxacephem is trival and low yielding. Therefore, discovery a Simple and productive synthetic method is very necessary. The inexpensive 6-Aminopenicillanic acid was used to obtain the 3-​chloromethyl oxacephem in our group.

Keywords
3-chloromethyl oxacephem
antibacterial activity
Latamoxef
Flomoxef.
Manuscript
Industrial Method for Preparing 3-Chloromethyl Oxacephem Antibiotic Nucleus.pdf
Design and Characterization of Polymeric Floating Microspheres of Levofloxacin Hemihydrate.
ISOLATION OF ANTICANCER AGENTS FROM Tabernaemontana divaricata (L.) R. Br. ex Roem. & Schult.