EventsThe 14th International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-14-00482
This submission belongs to the session b. Natural Products Chemistry of the event The 14th International Electronic Conference on Synthetic Organic Chemistry
Published date
31 Oct, 2010
Citation
Manuel M. Paz, The Reactions of Mitomycin C with Dithiols I. Reductive Activation, in Proceedings of The 14th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2010, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-14-00482
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The Reactions of Mitomycin C with Dithiols I. Reductive Activation

Manuel M. Paz 1
1. Departmento de Química Orgánica, Universidade de Santiago de Compostela, Facultade de Ciencias, Campus de Lugo, 27002 Lugo, Spain
Abstract
We report that the clinically used antitumor drug mitomycin C is reductively activated in vitro by simple thiols; a mechanism for this activation is proposed based on kinetic data and the identification of mitosene metabolites. The biological implications of these findings are discussed.
Keywords
Synthesis of 3-chlorohimachal-7-one
The Reactions of Mitomycin C with Dithiols II. Formation of Dithiol Cross-Links