EventsThe 14th International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-14-00484
This submission belongs to the session b. Natural Products Chemistry of the event The 14th International Electronic Conference on Synthetic Organic Chemistry
Published date
31 Oct, 2010
Citation
Manuel M. Paz, The Reactions of Mitomycin C with Dithiols III. Mysterious Reactions, in Proceedings of The 14th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2010, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-14-00484
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The Reactions of Mitomycin C with Dithiols III. Mysterious Reactions

Manuel M. Paz 1
1. Departmento de Química Orgánica, Universidade de Santiago de Compostela, Facultade de Ciencias, Campus de Lugo 27002 Lugo, Spain
Abstract
We report two unexpected findings ocurring after treatment of the antitumor drug mitomycin C with dithiols. The first finding relates to the reaction of mitomycin C with exactly one molar equivalent of dithiol to form a mitosene-like material with unusual physico-chemical properties. The second finding was the formation of unexpected dimeric mitosenes when the reaction of MC with dithiols was quenched at short reaction times. We hypothesize that both events are originated by an unprecedetended deaziridination reaction.
Keywords
The Reactions of Mitomycin C with Dithiols II. Formation of Dithiol Cross-Links
Microwave assisted synthesis of 1,3,5-tris(2-hydroxyethyl)isocyanurate carbamates with C3 symmetry