EventsMOL2NET'17, Conference on Molecular, Biomed., Comput. & Network Science and Engineering, 3rd ed.
Event submissions
Published
with-doi10.3390/mol2net-03-05105
This submission belongs to the session 02. CHEMBIOMOL-03: Chem. Biol. & Med. Chem. Workshop, Rostock, Germany-Bilbao, Spain-Galveston, Texas, USA, 2017 of the event MOL2NET'17, Conference on Molecular, Biomed., Comput. & Network Science and Engineering, 3rd ed.
Published date
20 Dec, 2017
Citation
Ander Alvaro, Aimar García, Esther Domínguez, Galder Llorente, Garazi Urgoitia, Iratxe Astarloa, María Teresa Herrero, Raul Sanmartin, Enaminoketone derivatives as key intermediates for the synthesis of 4-quinolones, in Proceedings of MOL2NET'17, Conference on Molecular, Biomed., Comput. & Network Science and Engineering, 3rd ed., 15 January–15 December 2017, MDPI: Basel, Switzerland, doi: 10.3390/mol2net-03-05105
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Enaminoketone derivatives as key intermediates for the synthesis of 4-quinolones

Ander Alvaro 1
Aimar García 1
Esther Domínguez 1
Galder Llorente 1
Garazi Urgoitia 1
Iratxe Astarloa 1
María Teresa Herrero 1
Raul Sanmartin 1
1. University of Basque Country
Abstract

N-substituted 4-quinolones can be obtained in good yields via intramolecular amine exchage reaction from N-substituted (E)-1-(2-aminophenyl)-3-(dimethylamino)prop-2-en-1-ones or, alternatively, from (E)-1-(2-aminophenyl)-3-(dimethylamino)prop-2-en-1-one through intramolecular amine exchange/N-benzylation. Both strategies can lead to N-(2-halobenzyl)-4-quinolones, functionalized substrates which could undergo further transformations to provide interesting polyheterocycles.

Keywords
4-quinolone
enaminoketone
amine exchange
Poster
mol2net-03_MOL2NET-2017 ANDER ALVAROv5-1.pdf
mol2net-03_MOL2NET-2017 ANDER ALVAROv5-1.pdf
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