EventsMOL2NET'18, Conference on Molecular, Biomed., Comput. & Network Science and Engineering, 4th ed.
Event submissions
Published
with-doi10.3390/mol2net-04-06085
This submission belongs to the session 06. CHEMBIOMOL-04: Chem. Biol. & Med. Chem. Workshop, Paraiba, Porto, Rostock, Germany-Galveston, Texas, USA, 2018 of the event MOL2NET'18, Conference on Molecular, Biomed., Comput. & Network Science and Engineering, 4th ed.
Published date
19 Dec, 2018
Citation
Rui João Loureiro, Diogo Vila-Viçosa, Miguel Machuqueiro, Eugene Shakhnovich, Patrícia Faísca, The importance of unstructured termini in the aggregation cascade of beta-2-microglobulin: insights from molecular simulations of D76N mutant, in Proceedings of MOL2NET'18, Conference on Molecular, Biomed., Comput. & Network Science and Engineering, 4th ed., 15 January 2018–20 January 2019, MDPI: Basel, Switzerland, doi: 10.3390/mol2net-04-06085
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The importance of unstructured termini in the aggregation cascade of beta-2-microglobulin: insights from molecular simulations of D76N mutant

Rui João Loureiro 1
Diogo Vila-Viçosa 1,2
image
Miguel Machuqueiro 1,2
Eugene Shakhnovich 3
Patrícia Faísca 1,4
1. BioISI – Biosystems and Integrative Sciences Institute, Faculdade de Ciências, Universidade de Lisboa
2. Centro de Química e Bioquímica, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade de Lisboa
3. Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusets
4. Departamento de Física, Faculdade de Ciências, Universidade de Lisboa
Abstract
Keywords
protein aggregation
amyloidosis
biophysics
computer modeling
conformational disorders
protein folding