EventsMOL2NET'18, Conference on Molecular, Biomed., Comput. & Network Science and Engineering, 4th ed.
Event submissions
Published
with-doi10.3390/mol2net-04-05433
This submission belongs to the session 03. CHEMBIOINFO-04: Chem-Bioinformatics Congress Cambridge, UK-Chapel Hill and Duluth, USA, 2018 of the event MOL2NET'18, Conference on Molecular, Biomed., Comput. & Network Science and Engineering, 4th ed.
Published date
11 Jul, 2018
Citation
Ashok K Dubey, Rajeev K Singla, Mohammed Ali, Isolation of Novel Hyaluronidase Inhibitor from the Hard Shell of Coconut, in Proceedings of MOL2NET'18, Conference on Molecular, Biomed., Comput. & Network Science and Engineering, 4th ed., 15 January 2018–20 January 2019, MDPI: Basel, Switzerland, doi: 10.3390/mol2net-04-05433
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Isolation of Novel Hyaluronidase Inhibitor from the Hard Shell of Coconut

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Rajeev K Singla 1
Mohammed Ali 2
Ashok K Dubey 3
1. Division of Biological Sciences an Engineering, Netaji Subhas Institute of Technology, Sector-3, Dwarka, New Delhi-110078, India
2. Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi, India
3. Department of Biological Sciences and Engineering, Netaji Subhas University of Technology, Dwarka, New Delhi 110078, India
Abstract

In the current study, we have isolated and characterized a novel molecule from the hard shell of Cocos nucifera Linn. and evaluated it for its inhibitory potential against hyaluronidase enzyme. Alcoholic extract of the hard shell was subjected to various purification procedures viz. column chromatography, solvent based extraction and TLC to yield a phytomolecule. Spectral characterization indicated that it is a novel keto fatty acid. To the best of our knowledge, this is the first keto fatty acid from the coconut plant even. Results of hyaluronidase inhibition assay indicated that it has moderate hyaluoronidase inhibitory activity.

Keywords
Hyaluronidase inhibitor
Cocos nucifera
Natural product
Poster
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