The Anti-Inflammatory Effects of the Zingiber officinale Roscoe

Introduction: The inflammatory process is one of the main means of protection of innate immunity, and this response only occurs when there is some injury, being of physical, chemical and biological causes. Inflammation has as main signals vasodilation, increases the permeability of the capillaries, allowing fluid to flow into the interstitial space, coagulation of the fluid in the interstitial space by the presence of large amounts of coagulation proteins, migration of leukocytes to tissues, and end products, their end products histamine, serotonin, prostaglandins and bradykinin. Zingiber officinale Roscoe popularly known as ginger, has been widely used in traditional medicine for the treatment of various diseases such as muscle aches, fever, sore throats, indigestion and vomiting. The objective of this work was to address the anti-inflammatory effects of the Zingiber officinale Roscoe plant. Methodology: Given the above, the present work is a review that aims to report articles that address the anti-inflammatory effects of the plant Zingiber officinale Roscoe, using bibliographic data. Results and Discussion: Anti-inflammatory drugs have the function of preventing this cascade of reactions, being steroidal anti-inflammatory drugs (AIEs), phospholipase A2 inhibitors and non-steroidal anti-inflammatory drugs (NSAIDs), cyclooxygenase inhibitors -1 and COX-2). Because these drugs have a number of adverse effects, some studies have shown the anti-inflammatory effect of Zingiber officinale Roscoe, popularly known as Ginger, where its main components, gingerols and shogaols, can inhibit the synthesis of several proinflammatory cytokines (IL-1, TNF-α and IL-6), chemokines, and inhibited the action of prostaglandins and the enzyme cyclooxygenase-2 (COX-2). In addition, ginger components have been shown to be more effective than conventional non-steroidal anti-inflammatory drugs (NSAIDs), with fewer side effects. Conclusion: Through the results obtained it has been demonstrated that Zingiber officinale Roscoe possesses a high anti- inflammatory.