Events4th International Electronic Conference on Medicinal Chemistry
Event submissions
Published
with-doi10.3390/ecmc-4-05595
This submission belongs to the session B. Posters of the event 4th International Electronic Conference on Medicinal Chemistry
Published date
31 Oct, 2018
Citation
Luis G. Alves, João F. Portel, Sílvia A. Sousa, Jorge H. Leitão, Ana M. Martins, Antibacterial activity of cyclam derivatives, in Proceedings of 4th International Electronic Conference on Medicinal Chemistry, 1 November–30 November 2018, MDPI: Basel, Switzerland, doi: 10.3390/ecmc-4-05595
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Antibacterial activity of cyclam derivatives

João F. Portel 1,2
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Luis G. Alves 3
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Sílvia A. Sousa 2
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Jorge H. Leitão 2
Ana M. Martins 1
1. Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa Av. Rovisco Pais 1, 1049-001 Lisboa, Portugal
2. iBB - Instituto de Bioengenharia e Biociências, Instituto Superior Técnico, Universidade de Lisboa Av. Rovisco Pais 1, 1049-001 Lisboa, Portugal
3. Centro de Química Estrutural, Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Av. Rovisco Pais 1, 1049-003 Lisboa, Portugal
Abstract

The steadily increasing of the resistance of human pathogens to multiple antimicrobials over the last decade is alarming and a serious threat to public health.[1] While the emergence of multidrug resistance has been associated with misuse and abuse of antimicrobials, the number of available effective agents is decreasing as novel compounds arriving into the market are scarce.[2,3]

Tetraazamacrocycles are versatile and readily tunable molecules with potential for the development of derivatives having enhanced antimicrobial activity. Our recent work led to the identification of cyclam derivatives as a potential novel class of compounds that represents a breakthrough in the field of new antibacterial drugs.[4]

[1] WHO. Antimicrobial Resistance: Global Report on Surveillance 2014; Geneva, 2014

[2] Bax, R.; Mullan N.; Verhoef, J., Int. J. Antimicrob. Agents 2000, 16, 51-59

[3] Norrby, S. R.; Nord, C. E.; Finch, R., Lancet Infect. Dis. 2005, 5, 115-119

[4] Alves, L. G.; Pinheiro, P. F.; Feliciano, J. R.; Leitão, J. H.; Martins, A. M., Int. J. Antimicrob. Agents 2017, 49, 646-649

Keywords
Cyclams
Azamacrocycles
Antimicrobials
Bacteria
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