Anti-inflammatory activity of new complex compounds SnCl4 with salicyloyl hydrazones benzaldehyde and 4-bromobenzaldehyde on different models of inflammation

The complex compounds SnCl4 with salicyloyl hydrazones benzaldehyde and 4-bromobenzaldehyde exhibit different pharmacological activities, one of which is anti-inflammatory. To study the correlation between structure and activity, we have studied the contribution to the overall anti-inflammatory activity of the components of this complex compounds, benzaldehydes and salicylic acid.

The study was conducted on the the histamine, trypsin, carrageenan and formalin models of the inflammation. During the modeling trypsin and histamine inflammation, the test substances were administered 30 minutes before the injection of the inflammatory agent. Treatment by oral administration of certain components began a day after the development of inflammation on the carrageenan inflammation model and three days later on the formalin model.

The obtained data indicate that the components of the complex compounds SnCl4 - benzaldehyde, 4-bromobenzaldehyde and salicylic acid have their own anti-inflammatory activity on models of short and long-term inflammation. Also, they make a contribution to the overall pharmacological activity of the studied compounds.