Medicinal plants are in rich source of antimicrobial agents. The present study was carried out to evaluate the antimicrobial effect plants from same species Brassica oleceracea namely, white cabbage and red cabbage The preliminary phytochemical analysis was tested by using different extract of these plants for the presence of various secondary metabolites like alkaloids, flavonoids, tannins, saponins, terpenoids, glycosides, steroids, carbohydrates and amino acids. The in vitro antimicrobial activity was screened against clinical isolates viz gram positive bacteria Staphylococcus aureus, Streptococcus pyogenes, gram negative bacteria Escherichia coli, Pseudomonas aeruginosa .Extracts were found significant inhibition against all the pathogens.