Event submissions
Published
This submission belongs to the session F. Symposium on Microwave Assisted Synthesis of the event The 22nd International Electronic Conference on Synthetic Organic Chemistry
Published date
14 Nov, 2018
Citation
Didier Farley Vargas Vargas, Enrique Leandro Larghi, Teodoro Saul Kaufman, A one-pot microwaves-mediated approach towards 3-methylisoquinolines from hydrazone-derived 1-azatrienes, in Proceedings of The 22nd International Electronic Conference on Synthetic Organic Chemistry, 15 November–15 December 2018, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-22-05676
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A one-pot microwaves-mediated approach towards 3-methylisoquinolines from hydrazone-derived 1-azatrienes
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Didier Farley Vargas Vargas 1
Enrique Leandro Larghi 1
Teodoro Saul Kaufman 1
1. Instituto de Química Rosario IQUIR (CONICET-UNR), and Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario (UNR), Suipacha 531 (2000) Rosario, Argentina.
Abstract
The use of hydrazone-type 1-azatriene derivatives for the synthesis of 3-methyl isoquinolines through a one pot microwave-assisted cyclization was developed and evaluated. The 1-azatrienes were generated by reaction of 2-propenylbenzaldehydes with hydrazines. Their subsequent electrocyclization gave rise to 3-methylisoquinolines, as well as to 3-methyl-3,4-dihydroisoquinolines as reaction by-products. The reaction conditions were optimized, and its scope and limitations were explored.
Keywords
Nitrogen heterocycles
3-methylisoquinoline synthesis
hydrazones
Manuscript
ECSOC-2018.pdf
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