Event submissions
Published
This submission belongs to the session C. keynote Presentation of the event 5th International Electronic Conference on Medicinal Chemistry
Published date
08 Nov, 2019
Citation
Maria M. M. Santos, Valentina Barcherini, Sara Gomes, Margarida Espadinha, Joana Soares, Liliana Raimundo, Célia Gomes, Flávio Reis, Alexandra Antunes, Lucília Saraiva, Tryptophanol-derived oxazoloisoindolinones: Novel small molecule p53 activators with promising antitumor activity, in Proceedings of 5th International Electronic Conference on Medicinal Chemistry, 1 November–30 November 2019, MDPI: Basel, Switzerland, doi: 10.3390/ECMC2019-06403
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Tryptophanol-derived oxazoloisoindolinones: Novel small molecule p53 activators with promising antitumor activity
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Valentina Barcherini 1
Sara Gomes 2
Margarida Espadinha 1
Joana Soares 2
Liliana Raimundo 2
Célia Gomes 3
Flávio Reis 3
Alexandra Antunes 4
Lucília Saraiva 2
Maria M. M. Santos 1
1. iMed.ULisboa, Faculdade de Farmácia da Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal
2. LAQV/REQUIMTE, Laboratório de Microbiologia, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal
3. Institute of Pharmacology & Experimental Therapeutics, Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, CNC.IBILI Consortium & CIBB Consortium, University of Coimbra, Coimbra, Portugal
4. Centro de Química Estrutural, Instituto Superior Técnico, University of Lisbon, Av. Rovisco Pais, 1049 001, Lisboa, Portugal
Abstract
Keywords
Cancer
MDMs
p53
tryptophanol
isoindolinone