Events The 22nd International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session A. Bioorganic, Medicinal and Natural Products Chemistry of the event The 22nd International Electronic Conference on Synthetic Organic Chemistry

Published date

14 Nov, 2018

Citation

Rui Pedro Carvalho Lima Sousa, João Carlos Canossa Ferreira, Maria João Marques Ferreira Sousa, Maria Sameiro Torres Gonçalves, New Nile Blue derivatives as NIR fluorescent probes and antifungal agents, in Proceedings of The 22nd International Electronic Conference on Synthetic Organic Chemistry, 15 November–15 December 2018, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-22-05693

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New Nile Blue derivatives as NIR fluorescent probes and antifungal agents

Rui Pedro Carvalho Lima Sousa ¹

João Carlos Canossa Ferreira ¹

Maria João Marques Ferreira Sousa ¹

Maria Sameiro Torres Gonçalves ¹

1. Universidade do Minho

Abstract

The development of new NIR fluorescent probes is a very important issue due to the wide range of applications. Benzo[a]phenoxazines are molecules with fluorescence at around 600 nm and have been reported also as antifungal agents. Herein, the synthesis of four new Nile Blue derivatives with hydrogen, propyl and/or aminopropyl groups as substituents of the amines of 5- and 9-positions is described. Photophysical properties are evaluated in acidified ethanol and aqueous solution at physiological pH. Antifungal activity is also evaluated through the obtention of MIC values.

Keywords

Benzo[a]phenoxazines

Nile Blue derivatives

NIR fluorescent probes

antifungal agents.

Manuscript

Procceding ECSOC22 final - with alterations.pdf

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