Events The 22nd International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session C. General Organic Synthesis of the event The 22nd International Electronic Conference on Synthetic Organic Chemistry

Published date

14 Nov, 2018

Citation

Wafa Saad Al-Harthi, Laila M Break, Synthesis new nucleoside of 1,3-bis-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-8-(trifluoromethyl)-2-methyl-4-quinazolinone, in Proceedings of The 22nd International Electronic Conference on Synthetic Organic Chemistry, 15 November–15 December 2018, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-22-05694

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Synthesis new nucleoside of 1,3-bis-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-8-(trifluoromethyl)-2-methyl-4-quinazolinone

Laila M Break ¹

Wafa Saad Al-Harthi ²

1. Taif University

2. Taif University, KSA

Abstract

Fluorinated nucleosides very important in increased biological and chemical stability of organ fluorine compounds. Synthesis of (1H)-8-trifluloromethyl-2-methyl-4-quinazolinone 3 from 2-amino-3-(trifluoromethyl) benzoic acid 1. Ribosylation of compound 4 with 1-O-acetyl-2,3,5-tri-O-benzoyl-

Keywords

1-O-Acetyl-2,3,5-trihydroxy--D-ribofuranose

Nucleosides

2-Methyl-4-quinazolinone

Trifluoromethylquinazolinone.

Manuscript

8CF3 2MeQ Nucleoside 2018.pdf

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