Events The 22nd International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

10.3390/ecsoc-22-05704 (registering DOI)

This submission belongs to the session C. General Organic Synthesis of the event The 22nd International Electronic Conference on Synthetic Organic Chemistry

Published date

14 Nov, 2018

Citation

Aissaoui Regadia, Khalifa Ahmed, Mokhtari ZINEB, Benhamida AISSA, Khamiss Kussay, Preparation of 1,2-benzylated derivatives polyfunctioned from O-salycilyl aldehyde and β-ketoesters, in Proceedings of The 22nd International Electronic Conference on Synthetic Organic Chemistry, 15 November–15 December 2018, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-22-05704

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Preparation of 1,2-benzylated derivatives polyfunctioned from O-salycilyl aldehyde and β-ketoesters

Aissaoui Regadia ^1,2

Khalifa Ahmed ³

Mokhtari ZINEB ¹

Benhamida AISSA ¹

Khamiss Kussay ¹

1. Department of Chemistry, Faculty of Exact Sciences and informatics, ZIANE Achour University of Djelfa, Algeria …………………………………………………………

2. Laboratoire de Synthèse Organique Appliquée, Université d'Oran Es-Senia, Oran 31000, Algerie

3. Department of Chemistry, Faculty of Exact Sciences and informatics, ZIANE Achour University of Djelfa, Algeria ………………………………………………

Abstract

Polyfunctionalized benzene derivatives 1 and 2 consist of important structural units in organic synthesis presente in certain molecules that existe in many and varied applications (pharmaceutical, biological, cosmetic ...). In this work, we have synthesized polyfunctionalized benzene derivatives 1, 2 from current and inexpensive reagents: β-ketoesters salicylic aldehyde and alkyl halides. The results obtained demonstrate the interesting strategy which has been chosen for the synthesis of this type of polyfunctionalized benzene derivatives 1.2. The compounds obtained spectroscopic analysis made it possible to identify the structure of the different products isolated in the form of a single stereoisomer designed as E-configuration. In fact, we have obtained the following seven condensation products:

1-(E)-methyl 2-(3-(2-(allyloxy)phenyl)acryloyl)pent-4-enoate

2-(E)-methyl 5-(2-(allyloxy)phenyl)-3-oxo-2-(prop-2-ynyl)pent-4-enoate

3-(E)-methyl 2-(3-(2-(but-3-enyloxy)phenyl)acryloyl)pent-4-enoate

4-(E)-methyl 5-(2-(but-3-enyloxy)phenyl)-3-oxo-2-(prop-2-ynyl)pent-4-enoate

5-(E)-methyl 2-(3-(2-(pent-4-enyloxy)phenyl)acryloyl)pent-4-enoate

6-(E)-methyl 3-oxo-5-(2-(pent-4-enyloxy)phenyl)-2-(prop-2-ynyl)pent-4-enoate

7-(E)-methyl 2-(3-(2-(prop-2-ynyloxy)phenyl)acryloyl)pent-4-enoate

Keywords

Polyfunctionalized 1,2 benzenic derivatives

β-ketoesters

O-Salicylic Aldehyde

Alkylation

Condensation.

Manuscript

Preparation of 1,2-benzylated derivatives polyfunctioned from O-salycilyl aldehyde and β-ketoesters.pdf

Poster

Preparation of 1,2-benzylated derivatives polyfunctioned from O-salycilyl aldehyde and β-ketoesters.pdf

Synthesis of an alkaline-earth metal organic frameworks (MOF) based on benzene-1,2,4,5 tetracarboxylic acid

Synthesis and study of the stability of phosphane palladacycles