EventsThe 15th International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-15-00581
This submission belongs to the session a. General Organic Synthesis of the event The 15th International Electronic Conference on Synthetic Organic Chemistry
Published date
31 Oct, 2011
Citation
Roshanak Najafi Moghaddamnejad, Samad Khaksar, Pentafluorophenylammonium triflate (PFPAT): an efficient, practical, and cost-effective organocatalyst for bigginelli reaction, in Proceedings of The 15th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2011, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-15-00581
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Pentafluorophenylammonium triflate (PFPAT): an efficient, practical, and cost-effective organocatalyst for bigginelli reaction

Roshanak Najafi Moghaddamnejad 1
Samad Khaksar 1
1. Chemistry Department, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran
Abstract
A simple, inexpensive, environmentally friendly and efficient route for the synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives via the one-pot three-component Biginelli reaction using pentafluorophenylammonium triflate (PFPAT) as a catalyst is described. PFPAT organocatalyst is air-stable, cost-effective, easy to handle, and easily removed from the reaction mixtures.
Keywords
Pentafluorophenylammonium triflate● Organocatalyst ● Acidity● 3,4-dihydropyrimidin-2(1H)-one● Biginelli
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